Androgenetic baldness: causes of alopecia
The most common cause of hair loss in both sexes is androgética baldness. This only occurs in those follicles of the scalp that have a genetic potential of being inhibited by androgen after a period of time.
Both men and women in skin androgen includes: androgenetic baldness, oily skin and acne. Women may also suffer from varying degrees of hirsutism.
Genetic factors
The expression of the gene that determines this baldness depends on the level of circulating androgens, there is no manifestation of baldness where there is no circulating androgens.
The genetic potential is expressed when the appropriate androgen comes into contact with the target cell receptor that is sensitive and androgen that is found in the hair papilla, or matrix, and the interaction with the receptor binding protein is expressed genetic material.
The hair more typically subjected to baldness androgenetic is located in the temporofrontal and in the crown of the scalp.
Baldness is a gradual process in which it becomes ever shorter phase anágena in each cycle.
In women androgenetic baldness is less severe, because there are fewer circulating androgens free and available to inhibit the follicles.
Control receivers and the mediators
With various illnesses alterations in hormonal balance have provided information on the relationship between androgens and alopecia.
Testicular feminization syndrome is caused by a resistance to testosterone (T) and 5-DHT. dehidrostestosterona (DHT), therefore there is no system of receptors for these hormones. Therefore, there is a development of the male reproductive tract, and there are no secondary sexual characteristics, and in addition (and this is what concerns us most) do not have acne, or androgenetic alopecia, or hair sex depends on androgens.
The clinical manifestations and biochemical testicular feminization syndrome and the deficit of 5-DHT receptor and seudohermafroditas type 2 suggest that the DHT is responsible for the gene expression of alopecia in the hair of the scalp.
Androgenetic baldness in normal women and hiperandrogenizadas
Some women with androgenetic baldness have a base of endocrinopathies. In that case there will be a crown or base of hyperandrogenism adrenal and presented signs of virility and / or hirsutism and / or acne depending on the severity of disorderly hormone. In some cases, however, there is no such hyperandrogenism and women presented androgenetic baldness, acne or hirsutism. There are some explanations for this:
a) Special hypersensitivity in the hair follicles and sebaceous glands to normal levels of androgens.
b) Whether it increases the metabolic utilization of the increased production of testosterone DHT at the peripheral level, in the skin and may increase the androgenetic baldness.
e) Also a decline in serum globulin conveyor androgens, an increase in free plasma androgens, which are really acting.
The poor production of this plasma protein in the liver can be settled by a deficient production of estrogen, or thyroid hormone, obesity or failing liver. It must be borne in mind that androgenetic alopecia, hirsutism and acne are exacerbated by Androgenic medications, including oral contraception (which contains progestins have an androgenic effect). There are few foods (peanut oil, wheat germ oil) and some dietary supplements that contain androgens (testosterone or dehidrostestosterona) detected by radioimmunoassay.
Vascularization and baldness androgenetic
There are no determinations of a minor irrigation in areas that are bald, nor a progressive decrease in the vascularization that could lead to hair loss in androgenetic alopecia. The male pattern baldness answered, rather than a loss of follicles at a time dependent gene expression and androgen decline in the growth phase of the hair, and possibly an extension of the phase of rest.
Diet and baldness androgenetic
The diet has a minor impact on the androgenetic baldness. But we can find some deficiencies in the diet that produce the specific and among other changes, disruption of the hair.
List what the main causes:
Food-Androgenic containing substances such as peanut oil and wheat germ (containing testosterone and DHT), can exacerbate the symptoms of androgenetic alopecia in women but not men since they have high levels of endogenous androgens.
- Protein-calorie malnutrition in its extreme form of merasma or Kwashiorkor characterized by anemia, edema, depigmentation of the skin, as well as changes in color and texture of hair (dry, brittle, reddish or black depending on the changing phases Malnutrition). It reduces the diameter of the hair bulb and there is an increase in hair loss.
-Diets to lose weight, a decrease of 10 to 25 kg. can lead to an increase in hairs on the scalp telógena phase and an increase in hair loss which will forward a few months. Being the parent of hair which has the highest turnover of cells of the body, is therefore not surprising that any protein or calorie restriction produces a decrease in their mitotic activity,
- Changes in the reserves or the contribution of various vitamins (A, B12, D, Biotin) can induce alterations in the hair as dryness, color change or collapse.
- The zinc and iron are essential for good health of your hair can cause a deficiency of diffuse hair loss